Drug interactions
Netupitant-palonosetron + Tranylcypromine
Severity: Major
Netupitant-palonosetron and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine is a nonselective irreversible MAO inhibitor with high serotonin syndrome liability, and 5-HT3 antagonists have also been associated with serotonin syndrome. Together they may increase the risk of severe serotonergic toxicity or hypertensive complications. Patients on MAO inhibitors are particularly vulnerable to additive agents.
What this interaction means in plain words
Netupitant-palonosetron and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from irreversible nonselective MAO inhibition and 5-HT3 receptor antagonism.
What to do
Prefer an antiemetic with no serotonergic activity, such as a different class, in patients taking tranylcypromine. If the combination is unavoidable, monitor closely for serotonin syndrome and stop the drugs if it appears.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Netupitant-palonosetron with Tranylcypromine?
MediHelp rates the interaction as major. Netupitant-palonosetron and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tranylcypromine is a nonselective irreversible MAO inhibitor with high serotonin syndrome liability, and 5-HT3 antagonists have also been associated with serotonin syndrome. Together they may increase the risk of severe serotonergic toxicity or hypertensive complications. Patients on MAO inhibitors are particularly vulnerable to additive agents.
How serious is the interaction between Netupitant-palonosetron and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic with no serotonergic activity, such as a different class, in patients taking tranylcypromine. If the combination is unavoidable, monitor closely for serotonin syndrome and stop the drugs if it appears.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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