Drug interactions
Netupitant-palonosetron + Vardenafil
Severity: Moderate
Netupitant-palonosetron and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant inhibits CYP3A4 moderately and may raise vardenafil concentrations. Increased exposure raises the risk of hypotension, headache, priapism and QT prolongation.
What this interaction means in plain words
Netupitant-palonosetron and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Vardenafil belongs to Genitourinary.
Why it happens
Netupitant inhibits CYP3A4-mediated metabolism of vardenafil.
What to do
Use a reduced vardenafil dose and avoid repeated dosing in short intervals. Monitor blood pressure and adverse effects, especially in older patients or those with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Netupitant-palonosetron with Vardenafil?
MediHelp rates the interaction as moderate. Netupitant-palonosetron and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant inhibits CYP3A4 moderately and may raise vardenafil concentrations. Increased exposure raises the risk of hypotension, headache, priapism and QT prolongation.
How serious is the interaction between Netupitant-palonosetron and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced vardenafil dose and avoid repeated dosing in short intervals. Monitor blood pressure and adverse effects, especially in older patients or those with cardiac risk factors.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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