Drug interactions
Netupitant / palonosetron + Voriconazole
Severity: Minor
Netupitant / palonosetron and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase netupitant exposure, since it is mainly cleared by CYP3A4. The clinical effect is usually modest and well tolerated.
What this interaction means in plain words
Netupitant / palonosetron and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of netupitant.
What to do
No dose adjustment is needed for a single-dose chemotherapy antiemetic regimen. Monitor for headache, constipation and QT-related symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Netupitant / palonosetron with Voriconazole?
MediHelp rates the interaction as minor. Netupitant / palonosetron and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole may increase netupitant exposure, since it is mainly cleared by CYP3A4. The clinical effect is usually modest and well tolerated.
How serious is the interaction between Netupitant / palonosetron and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed for a single-dose chemotherapy antiemetic regimen. Monitor for headache, constipation and QT-related symptoms.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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