Drug interactions
Netupitant-palonosetron + Voxelotor
Severity: Moderate
Netupitant-palonosetron and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and can raise exposure to CYP3A substrates such as netupitant. The clinical consequence is likely modest, with potentially more netupitant-related adverse effects.
What this interaction means in plain words
Netupitant-palonosetron and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, decreasing netupitant metabolism.
What to do
Monitor for netupitant adverse effects such as headache, constipation and fatigue. No routine dose change is required for a short antiemetic course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Netupitant-palonosetron with Voxelotor?
MediHelp rates the interaction as moderate. Netupitant-palonosetron and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and can raise exposure to CYP3A substrates such as netupitant. The clinical consequence is likely modest, with potentially more netupitant-related adverse effects.
How serious is the interaction between Netupitant-palonosetron and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for netupitant adverse effects such as headache, constipation and fatigue. No routine dose change is required for a short antiemetic course.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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