Drug interactions
Nicardipine + Nilotinib
Severity: Moderate
Nicardipine and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may increase nicardipine exposure, while nicardipine may raise nilotinib levels through efflux inhibition. Nilotinib prolongs the QT interval, so higher exposure is a concern.
What this interaction means in plain words
Nicardipine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4 metabolism of nicardipine, and nicardipine may inhibit P-glycoprotein efflux of nilotinib.
What to do
Monitor ECG for QTc prolongation and blood pressure. Correct electrolytes and reduce nicardipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nicardipine with Nilotinib?
MediHelp rates the interaction as moderate. Nicardipine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may increase nicardipine exposure, while nicardipine may raise nilotinib levels through efflux inhibition. Nilotinib prolongs the QT interval, so higher exposure is a concern.
How serious is the interaction between Nicardipine and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG for QTc prolongation and blood pressure. Correct electrolytes and reduce nicardipine dose if hypotension occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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