Drug interactions
Nicardipine + Oxcarbazepine
Severity: Moderate
Nicardipine and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine can induce CYP3A4 and lower nicardipine exposure. Blood pressure control may be reduced, particularly after oxcarbazepine is started or its dose is raised.
What this interaction means in plain words
Nicardipine and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine (via its active metabolite) weakly induces CYP3A4, increasing nicardipine metabolism.
What to do
Monitor blood pressure when starting or stopping oxcarbazepine. Increase the nicardipine dose if the response falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Nicardipine with Oxcarbazepine?
MediHelp rates the interaction as moderate. Nicardipine and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine can induce CYP3A4 and lower nicardipine exposure. Blood pressure control may be reduced, particularly after oxcarbazepine is started or its dose is raised.
How serious is the interaction between Nicardipine and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping oxcarbazepine. Increase the nicardipine dose if the response falls.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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