Drug interactions
Nicardipine + Prednisolone
Severity: Minor
Nicardipine and Prednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits P-glycoprotein and CYP3A4 to a modest degree, which might slightly raise prednisolone exposure. The effect is expected to be small and rarely clinically significant.
What this interaction means in plain words
Nicardipine and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Prednisolone belongs to Endocrine.
Why it happens
Nicardipine may inhibit P-glycoprotein and CYP3A4, slightly reducing prednisolone clearance.
What to do
No dose change is generally required; monitor for corticosteroid adverse effects with long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Prednisolone?
MediHelp rates the interaction as minor. Nicardipine and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine inhibits P-glycoprotein and CYP3A4 to a modest degree, which might slightly raise prednisolone exposure. The effect is expected to be small and rarely clinically significant.
How serious is the interaction between Nicardipine and Prednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor for corticosteroid adverse effects with long-term use.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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