Drug interactions
Nicardipine + Primidone
Severity: Moderate
Nicardipine and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized partly to phenobarbital, which induces CYP3A4 and can lower nicardipine concentrations. Reduced blood pressure or angina control may result.
What this interaction means in plain words
Nicardipine and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Primidone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by primidone and its phenobarbital metabolite increases nicardipine clearance.
What to do
Monitor blood pressure and symptoms and increase the nicardipine dose as needed. Re-evaluate the dose if primidone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Nicardipine with Primidone?
MediHelp rates the interaction as moderate. Nicardipine and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized partly to phenobarbital, which induces CYP3A4 and can lower nicardipine concentrations. Reduced blood pressure or angina control may result.
How serious is the interaction between Nicardipine and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms and increase the nicardipine dose as needed. Re-evaluate the dose if primidone is stopped.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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