Drug interactions
Nicardipine + Siponimod
Severity: Moderate
Nicardipine and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine has some CYP2C9 and CYP3A4 inhibitory activity and may raise siponimod exposure. The combination effect is uncertain but higher levels could increase bradycardia and other adverse effects.
What this interaction means in plain words
Nicardipine and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Siponimod belongs to Central Nervous System.
Why it happens
Possible inhibition of CYP2C9 and CYP3A4 reduces siponimod clearance.
What to do
Confirm the patient's CYP2C9 genotype is appropriate and monitor heart rate and adverse effects. Avoid if the patient is also on other agents that inhibit both pathways.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Nicardipine with Siponimod?
MediHelp rates the interaction as moderate. Nicardipine and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine has some CYP2C9 and CYP3A4 inhibitory activity and may raise siponimod exposure. The combination effect is uncertain but higher levels could increase bradycardia and other adverse effects.
How serious is the interaction between Nicardipine and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm the patient's CYP2C9 genotype is appropriate and monitor heart rate and adverse effects. Avoid if the patient is also on other agents that inhibit both pathways.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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