Drug interactions
Nicardipine + Suvorexant
Severity: Minor
Nicardipine and Suvorexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak CYP3A4 inhibitor and may modestly increase suvorexant exposure, potentially causing next-day somnolence and impaired driving. Strong inhibitors are the main concern, so the effect here is limited.
What this interaction means in plain words
Nicardipine and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Suvorexant belongs to Central Nervous System.
Why it happens
Nicardipine weakly inhibits CYP3A4, slightly reducing suvorexant clearance.
What to do
No dose change is usually needed; start suvorexant at the lowest dose and counsel about daytime drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Suvorexant
Frequently asked questions
Can I take Nicardipine with Suvorexant?
MediHelp rates the interaction as minor. Nicardipine and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a weak CYP3A4 inhibitor and may modestly increase suvorexant exposure, potentially causing next-day somnolence and impaired driving. Strong inhibitors are the main concern, so the effect here is limited.
How serious is the interaction between Nicardipine and Suvorexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; start suvorexant at the lowest dose and counsel about daytime drowsiness.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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