Drug interactions
Nicardipine + Tadalafil
Severity: Moderate
Nicardipine and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak CYP3A4 inhibitor, so any rise in tadalafil exposure is small. The combination may still add to blood-pressure lowering because both cause vasodilation.
What this interaction means in plain words
Nicardipine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation with mild CYP3A4 inhibition reducing tadalafil clearance.
What to do
Monitor blood pressure and counsel patients about dizziness and syncope. Start tadalafil at a low dose in patients on antihypertensives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Tadalafil?
MediHelp rates the interaction as moderate. Nicardipine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is a weak CYP3A4 inhibitor, so any rise in tadalafil exposure is small. The combination may still add to blood-pressure lowering because both cause vasodilation.
How serious is the interaction between Nicardipine and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel patients about dizziness and syncope. Start tadalafil at a low dose in patients on antihypertensives.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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