Drug interactions
Nicardipine + Tolvaptan
Severity: Minor
Nicardipine and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may raise tolvaptan exposure through P-glycoprotein inhibition, possibly increasing thirst, polyuria and rapid sodium correction.
What this interaction means in plain words
Nicardipine and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Tolvaptan belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein efflux of tolvaptan by nicardipine; CYP3A4 inhibition may also contribute.
What to do
No empirical dose change. Monitor serum sodium and volume status.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Nicardipine with Tolvaptan?
MediHelp rates the interaction as minor. Nicardipine and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine may raise tolvaptan exposure through P-glycoprotein inhibition, possibly increasing thirst, polyuria and rapid sodium correction.
How serious is the interaction between Nicardipine and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change. Monitor serum sodium and volume status.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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