Drug interactions
Nicardipine + Trabectedin
Severity: Moderate
Nicardipine and Trabectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak-to-moderate CYP3A4 inhibitor, and trabectedin is mainly metabolized by CYP3A4. Higher trabectedin exposure could increase hepatotoxicity, myelosuppression and rhabdomyolysis risk.
What this interaction means in plain words
Nicardipine and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Trabectedin belongs to Oncology.
Why it happens
Nicardipine inhibits CYP3A4-mediated metabolism of trabectedin, raising its plasma concentrations.
What to do
Prefer an alternative antihypertensive such as a non-CYP3A4-inhibiting agent during trabectedin cycles; if combined, monitor liver enzymes, CK and blood counts closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Trabectedin
Frequently asked questions
Can I take Nicardipine with Trabectedin?
MediHelp rates the interaction as moderate. Nicardipine and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is a weak-to-moderate CYP3A4 inhibitor, and trabectedin is mainly metabolized by CYP3A4. Higher trabectedin exposure could increase hepatotoxicity, myelosuppression and rhabdomyolysis risk.
How serious is the interaction between Nicardipine and Trabectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antihypertensive such as a non-CYP3A4-inhibiting agent during trabectedin cycles; if combined, monitor liver enzymes, CK and blood counts closely.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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