Drug interactions
Nicardipine + Vincristine
Severity: Moderate
Nicardipine and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may raise vincristine exposure via P-glycoprotein and CYP3A4 inhibition, potentially increasing neurotoxicity. Clinical evidence is limited.
What this interaction means in plain words
Nicardipine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Vincristine belongs to Oncology.
Why it happens
Possible inhibition of P-glycoprotein and CYP3A4 by nicardipine reduces vincristine clearance.
What to do
Monitor for peripheral neuropathy, constipation and ileus. Consider an alternative antihypertensive if neurotoxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Nicardipine with Vincristine?
MediHelp rates the interaction as moderate. Nicardipine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may raise vincristine exposure via P-glycoprotein and CYP3A4 inhibition, potentially increasing neurotoxicity. Clinical evidence is limited.
How serious is the interaction between Nicardipine and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, constipation and ileus. Consider an alternative antihypertensive if neurotoxicity emerges.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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