Drug interactions
Nifedipine + Nimodipine
Severity: Moderate
Nifedipine and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are dihydropyridine calcium channel blockers metabolized by CYP3A4, so combining them gives duplicate therapy with additive vasodilation. This can cause marked hypotension, flushing, headache and peripheral edema without added benefit.
What this interaction means in plain words
Nifedipine and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Nimodipine belongs to Cardiovascular.
Why it happens
Additive calcium channel blockade at vascular smooth muscle, with possible competition for CYP3A4 metabolism.
What to do
Avoid using two dihydropyridines together; choose one agent. If both are given, monitor blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Nifedipine with Nimodipine?
MediHelp rates the interaction as moderate. Nifedipine and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are dihydropyridine calcium channel blockers metabolized by CYP3A4, so combining them gives duplicate therapy with additive vasodilation. This can cause marked hypotension, flushing, headache and peripheral edema without added benefit.
How serious is the interaction between Nifedipine and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two dihydropyridines together; choose one agent. If both are given, monitor blood pressure closely.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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