Drug interactions
Nifedipine + Paclitaxel
Severity: Minor
Nifedipine and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is not a meaningful inhibitor of paclitaxel metabolism or transport at therapeutic doses, so a significant change in paclitaxel exposure is unlikely. No established clinical interaction exists.
What this interaction means in plain words
Nifedipine and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Paclitaxel belongs to Oncology.
Why it happens
Theoretical weak CYP3A4/P-glycoprotein interaction; no established clinical mechanism.
What to do
No dose change is needed; monitor for the usual paclitaxel toxicities such as neutropenia and neuropathy, and for hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Paclitaxel
Frequently asked questions
Can I take Nifedipine with Paclitaxel?
MediHelp rates the interaction as minor. Nifedipine and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is not a meaningful inhibitor of paclitaxel metabolism or transport at therapeutic doses, so a significant change in paclitaxel exposure is unlikely. No established clinical interaction exists.
How serious is the interaction between Nifedipine and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for the usual paclitaxel toxicities such as neutropenia and neuropathy, and for hypotension.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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