Drug interactions
Nifedipine + Quetiapine
Severity: Minor
Nifedipine and Quetiapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is mainly cleared by CYP3A4, but nifedipine is only a weak inhibitor, so any rise in quetiapine levels is likely small. Both drugs can cause hypotension, so additive blood pressure lowering and dizziness are more plausible concerns.
What this interaction means in plain words
Nifedipine and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Quetiapine belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition by nifedipine plus additive hypotensive effects.
What to do
No dose change is usually needed. Monitor for orthostatic hypotension and sedation, particularly at initiation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Nifedipine with Quetiapine?
MediHelp rates the interaction as minor. Nifedipine and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quetiapine is mainly cleared by CYP3A4, but nifedipine is only a weak inhibitor, so any rise in quetiapine levels is likely small. Both drugs can cause hypotension, so additive blood pressure lowering and dizziness are more plausible concerns.
How serious is the interaction between Nifedipine and Quetiapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for orthostatic hypotension and sedation, particularly at initiation.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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