Drug interactions
Nifedipine + Quinidine
Severity: Moderate
Nifedipine and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine may lower quinidine concentrations, and quinidine may increase nifedipine exposure through CYP3A4. The result can be reduced antiarrhythmic effect or more hypotension, flushing and edema. When either drug is started or stopped, the net effect is hard to predict.
What this interaction means in plain words
Nifedipine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Bidirectional CYP3A4-related pharmacokinetic effects alter the exposure to both drugs.
What to do
Monitor blood pressure, heart rate and quinidine levels and ECG when starting, stopping or changing the dose of either drug. Adjust doses according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Quinidine?
MediHelp rates the interaction as moderate. Nifedipine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nifedipine may lower quinidine concentrations, and quinidine may increase nifedipine exposure through CYP3A4. The result can be reduced antiarrhythmic effect or more hypotension, flushing and edema. When either drug is started or stopped, the net effect is hard to predict.
How serious is the interaction between Nifedipine and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and quinidine levels and ECG when starting, stopping or changing the dose of either drug. Adjust doses according to response.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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