Drug interactions
Nifedipine + Repaglinide
Severity: Minor
Nifedipine and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is metabolized by CYP3A4 and CYP2C8. Nifedipine is a weak CYP3A4 inhibitor, so a clinically meaningful increase in repaglinide exposure is unlikely, although hypoglycemia is possible in sensitive patients.
What this interaction means in plain words
Nifedipine and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition by nifedipine slightly reducing repaglinide metabolism.
What to do
No routine adjustment is needed. Counsel the patient on hypoglycemia symptoms and check glucose after starting nifedipine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Nifedipine with Repaglinide?
MediHelp rates the interaction as minor. Nifedipine and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repaglinide is metabolized by CYP3A4 and CYP2C8. Nifedipine is a weak CYP3A4 inhibitor, so a clinically meaningful increase in repaglinide exposure is unlikely, although hypoglycemia is possible in sensitive patients.
How serious is the interaction between Nifedipine and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Counsel the patient on hypoglycemia symptoms and check glucose after starting nifedipine.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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