Drug interactions
Nifedipine + Riociguat
Severity: Moderate
Nifedipine and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so combined use may cause additive hypotension. Nifedipine is not a strong CYP or P-gp inhibitor, so large pharmacokinetic effects are not expected.
What this interaction means in plain words
Nifedipine and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive pharmacodynamic effects.
What to do
Monitor blood pressure and symptoms of hypotension when starting or adjusting riociguat, and reduce either dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Nifedipine with Riociguat?
MediHelp rates the interaction as moderate. Nifedipine and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so combined use may cause additive hypotension. Nifedipine is not a strong CYP or P-gp inhibitor, so large pharmacokinetic effects are not expected.
How serious is the interaction between Nifedipine and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or adjusting riociguat, and reduce either dose if symptomatic.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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