Drug interactions
Nifedipine + Secobarbital
Severity: Moderate
Nifedipine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are enzyme inducers and can accelerate the metabolism of nifedipine, lowering its plasma concentrations. This may reduce blood pressure or angina control, particularly with repeated dosing.
What this interaction means in plain words
Nifedipine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of hepatic and intestinal CYP3A4 by secobarbital increases nifedipine clearance.
What to do
Monitor blood pressure or angina control and increase the nifedipine dose if needed. Reassess the dose if the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Nifedipine with Secobarbital?
MediHelp rates the interaction as moderate. Nifedipine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are enzyme inducers and can accelerate the metabolism of nifedipine, lowering its plasma concentrations. This may reduce blood pressure or angina control, particularly with repeated dosing.
How serious is the interaction between Nifedipine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure or angina control and increase the nifedipine dose if needed. Reassess the dose if the barbiturate is stopped.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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