Drug interactions
Nifedipine + Sufentanil
Severity: Moderate
Nifedipine and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is metabolized by CYP3A4, but nifedipine is not a meaningful inhibitor. The more relevant effect is additive hypotension during anesthesia, with severe hypotension reported when calcium channel blockers are combined with high-dose opioids.
What this interaction means in plain words
Nifedipine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive hemodynamic effects of vasodilation and opioid-induced bradycardia and vasodilation.
What to do
Monitor blood pressure and heart rate closely during induction and maintenance, and have fluids and vasopressors available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Nifedipine with Sufentanil?
MediHelp rates the interaction as moderate. Nifedipine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is metabolized by CYP3A4, but nifedipine is not a meaningful inhibitor. The more relevant effect is additive hypotension during anesthesia, with severe hypotension reported when calcium channel blockers are combined with high-dose opioids.
How serious is the interaction between Nifedipine and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely during induction and maintenance, and have fluids and vasopressors available.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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