Drug interactions
Nifedipine + Vardenafil
Severity: Moderate
Nifedipine and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and combined use may produce additive hypotension. Nifedipine is not a clinically significant CYP3A4 inhibitor, so the concern is mainly pharmacodynamic.
What this interaction means in plain words
Nifedipine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Vardenafil belongs to Genitourinary.
Why it happens
Additive vasodilation and blood pressure lowering from PDE5 inhibition and calcium channel blockade.
What to do
Start vardenafil at the lowest dose and monitor for symptomatic hypotension, especially on initiation and in volume-depleted or elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Vardenafil?
MediHelp rates the interaction as moderate. Nifedipine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and combined use may produce additive hypotension. Nifedipine is not a clinically significant CYP3A4 inhibitor, so the concern is mainly pharmacodynamic.
How serious is the interaction between Nifedipine and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start vardenafil at the lowest dose and monitor for symptomatic hypotension, especially on initiation and in volume-depleted or elderly patients.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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