Drug interactions
nifedipine + verapamil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Verapamil can increase nifedipine exposure with enhanced vasodilatory effects, leading to hypotension, dizziness, and peripheral edema.
Mechanism of action
Pharmacokinetic: Verapamil inhibits CYP3A4, increasing nifedipine concentrations; pharmacodynamic additive vasodilation.
Clinical management
Monitor BP and edema; consider reducing nifedipine dose when initiating verapamil or if adverse effects emerge.
Drug reference
References
- Procardia XL (nifedipine) Prescribing Information — Drug Interactions: CYP3A inhibitors (e.g., verapamil, diltiazem) — FDA Label
- Nifedipine: Drug Interactions — Lexicomp
Frequently asked questions
Can I take nifedipine with verapamil?
The interaction is rated: Moderate. Verapamil can increase nifedipine exposure with enhanced vasodilatory effects, leading to hypotension, dizziness, and peripheral edema.
How serious is the interaction between nifedipine and verapamil?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between nifedipine and verapamil managed?
Monitor BP and edema; consider reducing nifedipine dose when initiating verapamil or if adverse effects emerge.
Why do nifedipine and verapamil interact?
Pharmacokinetic: Verapamil inhibits CYP3A4, increasing nifedipine concentrations; pharmacodynamic additive vasodilation.
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