Drug interactions
Nifedipine + Warfarin
Severity: Minor
Nifedipine and Warfarin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine has been reported to produce small or inconsistent changes in warfarin response. Any effect is likely minor, since nifedipine is a weak CYP3A4 inhibitor and R-warfarin is the less potent enantiomer.
What this interaction means in plain words
Nifedipine and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
Possible weak inhibition of CYP3A4 metabolism of R-warfarin; evidence is inconsistent.
What to do
Check the INR after starting or stopping nifedipine and adjust the warfarin dose only if the INR changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Nifedipine with Warfarin?
MediHelp rates the interaction as minor. Nifedipine and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine has been reported to produce small or inconsistent changes in warfarin response. Any effect is likely minor, since nifedipine is a weak CYP3A4 inhibitor and R-warfarin is the less potent enantiomer.
How serious is the interaction between Nifedipine and Warfarin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the INR after starting or stopping nifedipine and adjust the warfarin dose only if the INR changes.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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