Drug interactions
Nilotinib + Nimodipine
Severity: Moderate
Nilotinib and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a moderate CYP3A4 inhibitor and may increase nimodipine exposure, causing hypotension. Nilotinib also prolongs the QT interval, which is not shared by nimodipine but warrants general cardiac vigilance.
What this interaction means in plain words
Nilotinib and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Nimodipine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by nilotinib reducing nimodipine clearance.
What to do
Monitor blood pressure and consider lowering the nimodipine dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Nimodipine?
MediHelp rates the interaction as moderate. Nilotinib and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is a moderate CYP3A4 inhibitor and may increase nimodipine exposure, causing hypotension. Nilotinib also prolongs the QT interval, which is not shared by nimodipine but warrants general cardiac vigilance.
How serious is the interaction between Nilotinib and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and consider lowering the nimodipine dose if hypotension develops.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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