Drug interactions
Nilotinib + Nizatidine
Severity: Moderate
Nilotinib and Nizatidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib absorption depends on an acidic gastric environment, and acid suppression can lower its exposure. This may reduce antineoplastic efficacy.
What this interaction means in plain words
Nilotinib and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Nizatidine raises gastric pH, reducing the solubility and absorption of nilotinib.
What to do
Give nizatidine about 10 hours before and 2 hours after nilotinib, or use an antacid separated from nilotinib by about 2 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Nizatidine?
MediHelp rates the interaction as moderate. Nilotinib and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib absorption depends on an acidic gastric environment, and acid suppression can lower its exposure. This may reduce antineoplastic efficacy.
How serious is the interaction between Nilotinib and Nizatidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give nizatidine about 10 hours before and 2 hours after nilotinib, or use an antacid separated from nilotinib by about 2 hours.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
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