Drug interactions
Nilotinib + Paclitaxel
Severity: Moderate
Nilotinib and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein and CYP enzymes in vitro and may increase paclitaxel exposure. Clinical data are scarce, but increased myelosuppression and neuropathy are possible.
What this interaction means in plain words
Nilotinib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Nilotinib inhibits P-glycoprotein and possibly CYP2C8/3A4, reducing paclitaxel clearance.
What to do
Monitor blood counts and neuropathy, and consider paclitaxel dose reduction if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Paclitaxel?
MediHelp rates the interaction as moderate. Nilotinib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits P-glycoprotein and CYP enzymes in vitro and may increase paclitaxel exposure. Clinical data are scarce, but increased myelosuppression and neuropathy are possible.
How serious is the interaction between Nilotinib and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy, and consider paclitaxel dose reduction if toxicity develops.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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