Drug interactions
Nilotinib + Prednisone
Severity: Moderate
Nilotinib and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and P-glycoprotein and could increase corticosteroid exposure, though the effect on prednisone is not well characterized. Additive immunosuppression and hyperglycemia may also be relevant in oncology patients.
What this interaction means in plain words
Nilotinib and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Prednisone belongs to Endocrine.
Why it happens
Nilotinib inhibition of CYP3A4 and P-glycoprotein may reduce prednisone clearance.
What to do
Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and infection, and reduce the prednisone dose if they emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Prednisone?
MediHelp rates the interaction as moderate. Nilotinib and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and P-glycoprotein and could increase corticosteroid exposure, though the effect on prednisone is not well characterized. Additive immunosuppression and hyperglycemia may also be relevant in oncology patients.
How serious is the interaction between Nilotinib and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and infection, and reduce the prednisone dose if they emerge.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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