Drug interactions
Nilotinib + Quetiapine
Severity: Major
Nilotinib and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and nilotinib inhibits CYP3A4, which may raise quetiapine exposure. Together they increase the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Nilotinib and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Quetiapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by nilotinib reducing quetiapine clearance.
What to do
Avoid the combination when possible; otherwise obtain baseline and follow-up ECGs and correct potassium and magnesium. Consider a lower quetiapine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Quetiapine?
MediHelp rates the interaction as major. Nilotinib and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and nilotinib inhibits CYP3A4, which may raise quetiapine exposure. Together they increase the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Nilotinib and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible; otherwise obtain baseline and follow-up ECGs and correct potassium and magnesium. Consider a lower quetiapine dose.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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