Drug interactions
Nilotinib + Quizartinib
Severity: Major
Nilotinib and Quizartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, so the combination markedly increases the risk of torsades de pointes. Nilotinib is also a CYP3A4 inhibitor and may raise quizartinib levels.
What this interaction means in plain words
Nilotinib and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Quizartinib belongs to Oncology.
Why it happens
Additive QT prolongation, plus CYP3A4 inhibition by nilotinib increasing quizartinib exposure.
What to do
Avoid if possible. If both are required, monitor ECGs frequently, correct electrolytes, and reduce the quizartinib dose as labeled for CYP3A4 inhibitors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Nilotinib with Quizartinib?
MediHelp rates the interaction as major. Nilotinib and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, so the combination markedly increases the risk of torsades de pointes. Nilotinib is also a CYP3A4 inhibitor and may raise quizartinib levels.
How serious is the interaction between Nilotinib and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If both are required, monitor ECGs frequently, correct electrolytes, and reduce the quizartinib dose as labeled for CYP3A4 inhibitors.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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