Drug interactions
Nilotinib + Riociguat
Severity: Moderate
Nilotinib and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib may raise riociguat exposure through CYP inhibition, which can cause symptomatic hypotension. The effect is likely smaller than with strong multi-pathway inhibitors.
What this interaction means in plain words
Nilotinib and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Riociguat belongs to Cardiovascular.
Why it happens
Nilotinib inhibits CYP3A4 and other pathways involved in riociguat clearance.
What to do
Monitor blood pressure and consider a lower riociguat starting dose, with downward titration if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Nilotinib with Riociguat?
MediHelp rates the interaction as moderate. Nilotinib and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib may raise riociguat exposure through CYP inhibition, which can cause symptomatic hypotension. The effect is likely smaller than with strong multi-pathway inhibitors.
How serious is the interaction between Nilotinib and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and consider a lower riociguat starting dose, with downward titration if hypotension occurs.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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