Drug interactions
Nilotinib + Sarecycline
Severity: Minor
Nilotinib and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline may inhibit P-glycoprotein, which could slightly raise nilotinib exposure. The clinical significance is probably small, but nilotinib has a QT liability that depends on exposure.
What this interaction means in plain words
Nilotinib and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nilotinib belongs to Oncology; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible P-glycoprotein inhibition by sarecycline reducing nilotinib efflux.
What to do
No routine dose change is needed. Follow standard nilotinib ECG monitoring and watch for adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Nilotinib with Sarecycline?
MediHelp rates the interaction as minor. Nilotinib and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline may inhibit P-glycoprotein, which could slightly raise nilotinib exposure. The clinical significance is probably small, but nilotinib has a QT liability that depends on exposure.
How serious is the interaction between Nilotinib and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Follow standard nilotinib ECG monitoring and watch for adverse effects.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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