Drug interactions
Nilotinib + Saxagliptin-metformin
Severity: Moderate
Nilotinib and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib commonly causes hyperglycemia and can worsen glycemic control in patients with diabetes. This may reduce the effectiveness of saxagliptin-metformin.
What this interaction means in plain words
Nilotinib and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as nilotinib is associated with hyperglycemia, probably via insulin resistance, though the mechanism is not fully clear.
What to do
Check glucose and HbA1c before and regularly during nilotinib therapy, and intensify antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Nilotinib and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib commonly causes hyperglycemia and can worsen glycemic control in patients with diabetes. This may reduce the effectiveness of saxagliptin-metformin.
How serious is the interaction between Nilotinib and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose and HbA1c before and regularly during nilotinib therapy, and intensify antidiabetic treatment as needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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