Drug interactions
Nilotinib + Selexipag
Severity: Moderate
Nilotinib and Selexipag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib may inhibit CYP2C8, which metabolizes selexipag and its active metabolite. Exposure may increase, along with prostacyclin-related adverse effects such as headache, hypotension and flushing.
What this interaction means in plain words
Nilotinib and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Selexipag belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C8-mediated metabolism of selexipag by nilotinib.
What to do
Monitor for prostacyclin-related adverse effects and consider reducing the selexipag dose frequency if poorly tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Nilotinib with Selexipag?
MediHelp rates the interaction as moderate. Nilotinib and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib may inhibit CYP2C8, which metabolizes selexipag and its active metabolite. Exposure may increase, along with prostacyclin-related adverse effects such as headache, hypotension and flushing.
How serious is the interaction between Nilotinib and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for prostacyclin-related adverse effects and consider reducing the selexipag dose frequency if poorly tolerated.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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