Drug interactions
Nilotinib + Sufentanil
Severity: Moderate
Nilotinib and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is cleared mainly by CYP3A4, and nilotinib can inhibit this enzyme. Higher sufentanil levels could increase opioid effects including sedation and respiratory depression. Nilotinib also prolongs QT, though sufentanil has little QT effect.
What this interaction means in plain words
Nilotinib and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Sufentanil belongs to Musculoskeletal.
Why it happens
Nilotinib inhibition of CYP3A4 reduces sufentanil clearance.
What to do
Monitor sedation and respiratory rate, and titrate sufentanil to effect using the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Nilotinib with Sufentanil?
MediHelp rates the interaction as moderate. Nilotinib and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is cleared mainly by CYP3A4, and nilotinib can inhibit this enzyme. Higher sufentanil levels could increase opioid effects including sedation and respiratory depression. Nilotinib also prolongs QT, though sufentanil has little QT effect.
How serious is the interaction between Nilotinib and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, and titrate sufentanil to effect using the lowest effective dose.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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