Drug interactions
Nilotinib + Thioridazine
Severity: Contraindicated
Nilotinib and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib carries a boxed warning for QT prolongation and is also a CYP2D6 inhibitor, which can increase thioridazine concentrations. Thioridazine's QT effect is concentration dependent, so the combination substantially raises the risk of torsades de pointes and sudden death.
What this interaction means in plain words
Nilotinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nilotinib belongs to Oncology; Thioridazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus CYP2D6 inhibition by nilotinib reducing thioridazine clearance.
What to do
Do not combine; use an alternative antipsychotic with minimal QT liability.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Thioridazine?
MediHelp rates the interaction as contraindicated. Nilotinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nilotinib carries a boxed warning for QT prolongation and is also a CYP2D6 inhibitor, which can increase thioridazine concentrations. Thioridazine's QT effect is concentration dependent, so the combination substantially raises the risk of torsades de pointes and sudden death.
How serious is the interaction between Nilotinib and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative antipsychotic with minimal QT liability.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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