Drug interactions
Nilotinib + Topotecan
Severity: Moderate
Nilotinib and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein and BCRP, which may increase topotecan exposure, particularly of the oral form. This could increase myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Nilotinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Topotecan belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein and BCRP efflux transport raises topotecan absorption and reduces elimination.
What to do
Avoid oral topotecan with nilotinib; with intravenous topotecan, monitor blood counts closely and reduce the dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Nilotinib with Topotecan?
MediHelp rates the interaction as moderate. Nilotinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits P-glycoprotein and BCRP, which may increase topotecan exposure, particularly of the oral form. This could increase myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Nilotinib and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral topotecan with nilotinib; with intravenous topotecan, monitor blood counts closely and reduce the dose if toxicity develops.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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