Drug interactions
Nilotinib + Verapamil
Severity: Major
Nilotinib and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib prolongs the QT interval and its exposure can rise with CYP3A4 and P-gp inhibitors like verapamil. Nilotinib may also increase verapamil levels, adding to bradycardia and hypotension risk.
What this interaction means in plain words
Nilotinib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4 and P-gp, increasing nilotinib exposure, while nilotinib inhibits CYP3A4 and may raise verapamil levels.
What to do
Avoid the combination where possible, or monitor ECG and QTc, electrolytes and heart rate closely. Consider reducing the nilotinib dose per labeling if a strong inhibitor effect is expected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Verapamil?
MediHelp rates the interaction as major. Nilotinib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib prolongs the QT interval and its exposure can rise with CYP3A4 and P-gp inhibitors like verapamil. Nilotinib may also increase verapamil levels, adding to bradycardia and hypotension risk.
How serious is the interaction between Nilotinib and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor ECG and QTc, electrolytes and heart rate closely. Consider reducing the nilotinib dose per labeling if a strong inhibitor effect is expected.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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