Drug interactions
Nilotinib + Vinblastine
Severity: Moderate
Nilotinib and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein and weakly CYP3A4, which may increase vinblastine exposure. This could worsen myelosuppression and neurotoxicity.
What this interaction means in plain words
Nilotinib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Nilotinib inhibits P-glycoprotein efflux and weakly inhibits CYP3A4 metabolism of vinblastine.
What to do
Monitor blood counts and neurotoxicity, and reduce the vinblastine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Vinblastine?
MediHelp rates the interaction as moderate. Nilotinib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits P-glycoprotein and weakly CYP3A4, which may increase vinblastine exposure. This could worsen myelosuppression and neurotoxicity.
How serious is the interaction between Nilotinib and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity, and reduce the vinblastine dose if toxicity develops.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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