Drug interactions
Nilotinib + Voclosporin
Severity: Major
Nilotinib and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase arrhythmia risk. Nilotinib may also raise voclosporin levels via CYP3A4 and P-glycoprotein inhibition, increasing nephrotoxicity.
What this interaction means in plain words
Nilotinib and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QT prolongation, with nilotinib inhibition of CYP3A4 and P-glycoprotein raising voclosporin exposure.
What to do
Avoid if possible. If combined, monitor ECG, electrolytes, renal function and blood pressure, and consider reducing the voclosporin dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Nilotinib with Voclosporin?
MediHelp rates the interaction as major. Nilotinib and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may increase arrhythmia risk. Nilotinib may also raise voclosporin levels via CYP3A4 and P-glycoprotein inhibition, increasing nephrotoxicity.
How serious is the interaction between Nilotinib and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If combined, monitor ECG, electrolytes, renal function and blood pressure, and consider reducing the voclosporin dose.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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