Drug interactions
Nilotinib + Vonoprazan
Severity: Moderate
Nilotinib and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan strongly suppresses gastric acid, which may lower nilotinib absorption, particularly with the capsule formulation, and reduce its anticancer effect.
What this interaction means in plain words
Nilotinib and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Raised gastric pH reduces the solubility and absorption of nilotinib, which depends on an acidic environment.
What to do
Avoid the combination where possible, or consider a formulation less affected by pH and monitor response and nilotinib levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Vonoprazan?
MediHelp rates the interaction as moderate. Nilotinib and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan strongly suppresses gastric acid, which may lower nilotinib absorption, particularly with the capsule formulation, and reduce its anticancer effect.
How serious is the interaction between Nilotinib and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or consider a formulation less affected by pH and monitor response and nilotinib levels.
What other medicines interact with Vonoprazan?
MediHelp also lists interactions of Vonoprazan with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Vonoprazan page.
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