Drug interactions
Nilutamide + Paclitaxel protein bound
Severity: Minor
Nilutamide and Paclitaxel protein bound: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilutamide may weakly inhibit CYP3A4 and CYP2C8 pathways involved in paclitaxel clearance, which could modestly increase paclitaxel exposure. The clinical significance is likely small.
What this interaction means in plain words
Nilutamide and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nilutamide may weakly inhibit CYP3A4-mediated metabolism of paclitaxel.
What to do
Monitor for increased neutropenia and neuropathy. No routine dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nilutamide
Frequently asked questions
Can I take Nilutamide with Paclitaxel protein bound?
MediHelp rates the interaction as minor. Nilutamide and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilutamide may weakly inhibit CYP3A4 and CYP2C8 pathways involved in paclitaxel clearance, which could modestly increase paclitaxel exposure. The clinical significance is likely small.
How serious is the interaction between Nilutamide and Paclitaxel protein bound?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased neutropenia and neuropathy. No routine dose adjustment is needed.
What other medicines interact with Nilutamide?
MediHelp also lists interactions of Nilutamide with, for example, Dihydroergotamine intranasal, Mavacamten, Artemether / lumefantrine. The full list is on the Nilutamide page.
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