Drug interactions
Nilutamide + Phenytoin
Severity: Moderate
Nilutamide and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilutamide may inhibit the metabolism of phenytoin and raise its concentrations, leading to toxicity such as nystagmus, ataxia or sedation.
What this interaction means in plain words
Nilutamide and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilutamide belongs to Endocrine; Phenytoin belongs to Central Nervous System.
Why it happens
Nilutamide inhibits hepatic oxidative metabolism of phenytoin.
What to do
Monitor phenytoin levels and for toxicity after starting nilutamide, and reduce the phenytoin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Nilutamide
Frequently asked questions
Can I take Nilutamide with Phenytoin?
MediHelp rates the interaction as moderate. Nilutamide and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilutamide may inhibit the metabolism of phenytoin and raise its concentrations, leading to toxicity such as nystagmus, ataxia or sedation.
How serious is the interaction between Nilutamide and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and for toxicity after starting nilutamide, and reduce the phenytoin dose if needed.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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