Drug interactions
Nilutamide + Theophylline
Severity: Moderate
Nilutamide and Theophylline: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilutamide inhibits hepatic enzymes and may reduce the clearance of drugs with a narrow therapeutic index, such as theophylline. This could raise concentrations and the risk of toxicity.
What this interaction means in plain words
Nilutamide and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilutamide belongs to Endocrine; Theophylline belongs to Respiratory.
Why it happens
Nilutamide inhibits hepatic cytochrome P450 enzymes, reducing theophylline metabolism.
What to do
Monitor theophylline levels and reduce the dose if concentrations rise or toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
- Nilutamide - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Nilutamide
Frequently asked questions
Can I take Nilutamide with Theophylline?
MediHelp rates the interaction as moderate. Nilutamide and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilutamide inhibits hepatic enzymes and may reduce the clearance of drugs with a narrow therapeutic index, such as theophylline. This could raise concentrations and the risk of toxicity.
How serious is the interaction between Nilutamide and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline levels and reduce the dose if concentrations rise or toxicity appears.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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