Drug interactions
Nilutamide + Vincristine liposomal
Severity: Moderate
Nilutamide and Vincristine liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is cleared via CYP3A4, so a CYP3A4 inhibitor could raise its exposure and increase neurotoxicity. Nilutamide is at most a weak inhibitor, so the effect is probably small.
What this interaction means in plain words
Nilutamide and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nilutamide may inhibit CYP3A4, reducing vincristine metabolism.
What to do
Monitor for peripheral neuropathy, constipation and other signs of vincristine toxicity. Reduce the vincristine dose if neurotoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilutamide
Frequently asked questions
Can I take Nilutamide with Vincristine liposomal?
MediHelp rates the interaction as moderate. Nilutamide and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vincristine is cleared via CYP3A4, so a CYP3A4 inhibitor could raise its exposure and increase neurotoxicity. Nilutamide is at most a weak inhibitor, so the effect is probably small.
How serious is the interaction between Nilutamide and Vincristine liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, constipation and other signs of vincristine toxicity. Reduce the vincristine dose if neurotoxicity develops.
What other medicines interact with Nilutamide?
MediHelp also lists interactions of Nilutamide with, for example, Dihydroergotamine intranasal, Mavacamten, Artemether / lumefantrine. The full list is on the Nilutamide page.
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