Drug interactions
Nimodipine + Oxcarbazepine
Severity: Moderate
Nimodipine and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak CYP3A4 inducer and may lower nimodipine concentrations, reducing efficacy. The effect is typically smaller than with carbamazepine.
What this interaction means in plain words
Nimodipine and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nimodipine belongs to Cardiovascular; Oxcarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by oxcarbazepine and its metabolite increasing nimodipine metabolism.
What to do
Monitor clinical response and blood pressure, adjusting nimodipine if effect appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Nimodipine with Oxcarbazepine?
MediHelp rates the interaction as moderate. Nimodipine and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weak CYP3A4 inducer and may lower nimodipine concentrations, reducing efficacy. The effect is typically smaller than with carbamazepine.
How serious is the interaction between Nimodipine and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and blood pressure, adjusting nimodipine if effect appears reduced.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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