Drug interactions
Nimodipine + Tadalafil
Severity: Moderate
Nimodipine and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nimodipine lowers blood pressure and tadalafil adds vasodilation, so additive hypotension may occur. This can be relevant in patients receiving nimodipine for subarachnoid hemorrhage where blood pressure is carefully controlled.
What this interaction means in plain words
Nimodipine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nimodipine belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and calcium channel blockade.
What to do
Monitor blood pressure closely if used together and avoid starting tadalafil during acute nimodipine therapy for subarachnoid hemorrhage unless essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Nimodipine with Tadalafil?
MediHelp rates the interaction as moderate. Nimodipine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nimodipine lowers blood pressure and tadalafil adds vasodilation, so additive hypotension may occur. This can be relevant in patients receiving nimodipine for subarachnoid hemorrhage where blood pressure is carefully controlled.
How serious is the interaction between Nimodipine and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely if used together and avoid starting tadalafil during acute nimodipine therapy for subarachnoid hemorrhage unless essential.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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