Drug interactions
Niraparib + Oxaliplatin
Severity: Moderate
Niraparib and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause myelosuppression, and niraparib commonly causes thrombocytopenia, anemia and neutropenia. Combined use can deepen and prolong cytopenias, increasing the risk of infection and bleeding.
What this interaction means in plain words
Niraparib and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Niraparib belongs to Oncology; Oxaliplatin belongs to Oncology.
Why it happens
Additive bone marrow suppression from a PARP inhibitor and a platinum cytotoxic.
What to do
Monitor complete blood counts frequently and interrupt or reduce the dose of either drug for significant cytopenias. Counsel patients to report fever or bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Niraparib
- Niraparib + Siponimod Moderate
Frequently asked questions
Can I take Niraparib with Oxaliplatin?
MediHelp rates the interaction as moderate. Niraparib and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause myelosuppression, and niraparib commonly causes thrombocytopenia, anemia and neutropenia. Combined use can deepen and prolong cytopenias, increasing the risk of infection and bleeding.
How serious is the interaction between Niraparib and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and interrupt or reduce the dose of either drug for significant cytopenias. Counsel patients to report fever or bleeding.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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