Drug interactions
Nirmatrelvir / ritonavir + Rosuvastatin
Severity: Moderate
Nirmatrelvir / ritonavir and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted nirmatrelvir can modestly increase rosuvastatin concentrations. Because the course is short, the risk is usually manageable.
What this interaction means in plain words
Nirmatrelvir / ritonavir and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ritonavir inhibits OATP1B1 and BCRP transporters, raising rosuvastatin exposure; CYP3A4 plays only a minor role.
What to do
Consider temporarily withholding rosuvastatin during the 5-day course, or continue with counselling to report muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Frequently asked questions
Can I take Nirmatrelvir / ritonavir with Rosuvastatin?
MediHelp rates the interaction as moderate. Nirmatrelvir / ritonavir and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted nirmatrelvir can modestly increase rosuvastatin concentrations. Because the course is short, the risk is usually manageable.
How serious is the interaction between Nirmatrelvir / ritonavir and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider temporarily withholding rosuvastatin during the 5-day course, or continue with counselling to report muscle pain or weakness.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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